Allogeneic Bone Marrow / Stem Cell Transplant
What is Bone Marrow Transplant (BMT)?
- Bone marrow is a semi-solid tissue which may be found within the spongy or cancellous portions of bones.
- A bone marrow transplant is a procedure where a damaged or destroyed bone marrow is replaced by healthy bone marrow stem cells.
Allogeneic Bone Marrow Transplant (BMT)
- Allogenic Bone Marrow Transplant involves taking stem cells from a donor that can be a relative.
- The donor must at least partly match your genes for successful transplant. The most effective way to match patients and donors is through human leukocyte antigen (HLA) matching, also called histocompatibility testing or tissue typing.
- HLAs are proteins covering most cells that dictate a person’s tissue type. The overall transplant survival is much higher when the degree of HLA match between the recipient and donor is high.
- The indications of Allogeneic BMT might include non-malignant diseases, bone marrow failure states, immunodeficiency states, metabolic disorders, hemoglobinopathies and malignant diseases.